Simple answer with a very complex explanation.
People with weapons that have ratings that match their ego level that have the right synergy mods, good rolls, maxed weapon skill and the right damage/weapon type for the boss will do the most damage to it... always.
Plus the lower the risk, the less health the boss has and the lower level of the TYPE of boss you'll get also. Which makes a MASSIVE difference between say a 4 and a 10.
As far as the explanation, I'd have to defer to the data website because there is far to much to cover here.



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