Not recommended. You need to worry about the temporary effects in the game that lower Fire's effectiveness, like Armor Plates and Shields. I use a Scourge to apply Bio to a massive amount of targets and a Flashbang to stun them (since targets set on Fire tend to run away) or remove the Shield penalty that I would normally encounter with a Fire weapon. This way, I have 3 Nano Effects at my disposal in 1 Loadout.
You also have the option of taking a Nano Effect that has no apparent weakness and making it stronger. If you're running with a Bio weapon, Shrill or Pyro will increase your DPS against targets.
To answer the OP, the best Grenade will vary from player to player depending on their Loadout. I have Bio, Flash, and Pyro equipped an equal amount of times between my 6 Loadouts.



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