Interesting and effective perk/skill combos?

[WeirdManBoy]

If you decide to start with Overcharge, look at getting Preparedness. It's also not too far from Decoy.

It automatically reloads the weapon you aren't currently using in your loadout over time. I really like it.

Yeah, this'll probably be part of my endgame double LMG loadout. Wish it had ammo regen as well, but that'd be a little OP and would make the other ammo regen skills useless.

[LunaticFate]

Could run LMG/Infector so you'd at least have dual ammo pools to draw from. I imagine dual LMGs would be murder on your ammo. Haven't worked with infectors at all so I'm not familiar with their damage potential.

Preparedness is one of my staple perks, though. Unload the primary AR/LMG, switch over to the Deto/Shotgun and work some things over, switch back, drop some more enemies. Never stop shooting. Tend to lead Co-Op by 200k - 300k damage since I made that switch.

[Zumacalis]

All of that sounds good. My original plan to go Decoy and be tanky and sometimes use healing guns kinda fell off the truck. Since there's no real taunt or anything it wouldn't work the way it does in other mmos. It might work in a more TF2 way if i had someone healing me.

I might go blur at the start and run around like Lilith in Borderlands just mowing things down with hipfire.

[Opus]

I typically use an auto shotgun and AR/SMG/LMG. Sometimes I use infectors as well. I have the following setup, at Ego 409, all maxed:

Overcharge: +30% damage

Perks:

-- Killing Machine: +6 second overcharge duration
-- Quick Charge: -9 second on OC recharge (if that makes sense)
-- Thick Skinned: 1/2 damage after shield breaks for 3 seconds. I run a respark, so my shield starts charging up after 3 secs.
-- Fortitude: +225HP

Next perk will be Overload, which will give me 30% faster reload on weapons. Not so important on SMGs, but will come in handy for the LMGs, shotties, etc.

[WaGzy]

Cloak with all the +Crit bonuses and a Wolfhound pistol with Dark Matter effect is INSANE damage, out damaging people in Co-op's by 200-300k

PS: You need to go for head shots, I find it super easy with practice, plus I love pistols.