I'm not a skilled player by any means but during my first story played through I did all the missions and side missions solo and rarely had a problem. I actually died no more than a handful of times. Every now and then I had difficulty when the area removed the options for tactics like on the docks when flanking and and making sure you swept through leaving no routes to be flanked were impossible.
Without being insulting I would just say if someone is having that much trouble it might help to work on different approach methods to combat. I'm a Combat Veteran so what may seem like common sense to me may not be for some but a little research might go a long way. I know it's a game and not similar to real fighting but that doesn't mean things like using range, cover, elevation and tactical retreats aren't adaptable. Weapons are tools and each scenario can benefit from a unique combination of strategy and tool selection. Don't limit yourself. Also try using a different power in each loadout with certain combinations of weapons that compliment them to switch on the fly and adapt. I like to use SAW's for overcharge because of the high damage and huge drum sizes of 110 rounds + and sniper rifles with stealth to hop from vantage point to vantage point and pick off mobs before they can track me down. Those are obviously just my personal choices and they work for me, sometimes. I still try new things all the time because you never really know and I want to have fun with it too. Some people may think they have the "right" combinations figured out but it's going to be different for everyone. I say find some decent combinations of functionality and fun that work for you and screw everyone else's opinions. Fun and functional usually go hand in hand anyway..
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DO YOU EVEN FLAREGUN BRO?
The original Northstar Flare users.
im telling you just rush dark matter you have a better chance to survive up close to them baiting them to try melee you and it makes them appear to take there time as if there computing what to do..... dark matter have smgs with fall off dmg + 9000 im telling you 2 dark matter out snipe you pretty damn easy with there smgs....
Have you noticed the enemy A.I. Snipers tend to aim for the head... A LOT...